The dosage of aciclovir should be reduced in patients with impaired renal function.
Adequate fluid intake is recommended to prevent acute renal failure or precipitation of aciclovir crystals in the renal tubules.
Therapy should be initiated as soon as possible after a diagnosis of chickenpox or herpes zoster, or at the first sign or symptom of an outbreak of genital herpes.
Usual Adult Dose: See Table 1.
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)
Usual Dose in Children: See Table 2.
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)
Dosing may be more accurately calculated as 20 mg/kg body weight (not to exceed 800 mg) aciclovir every 6 hours.
Recommended Oral Dose in Patients with Impaired Renal Function: See Table 3.
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)